Too Many Materials and Too Many Applications: An Experimental Problem Waiting for a Computational Solution

How many "me-too" drugs is too many?

ON AUGUST 3, 2009, THE US FOOD AND DRUG ADministration (FDA) approved pitavastatin (Livalo), making it the eighth statin approved for use in the United States and seventh currently available for sale. This approval comes almost a quarter century after that for the first member of the class, lovastatin, 8 years after generic lovastatin was approved and 4 years after 2 additional statins, pravast...

Therapeutic cytapheresis: too many platelets, too many white blood cells.

Myeloproliferative disorders may present with thrombocytosis and/or leukocytosis with symptoms ranging from minor to life-threatening. Therapeutic cytapheresis (TC), the removal of excess and/or abnormal cells such as platelets and white blood cells, can be used to rapidly reduce cells in the symptomatic patient. The patient's clinical status determines the need for TC as symptoms may not corre...

Too many men: the violence problem?

There is a strong intuitive expectation in both popular lore and conventional evolutionary thinking that more males lead to more violence. Here, we untangle the logic behind this widely held notion with a specific focus on humans. We first review the relation between the intensity of sexual selection in human populations and the adult sex ratio (ASR), and find that it is more in line with recen...

Too few physicians, or too many?

Rate Changes – Too many or too few ?